5-Hydroxytryptamine receptors in isolated rat ileum
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چکیده
منابع مشابه
Pharmacological analysis of 5-hydroxytryptamine receptors in isolated intracranial and extracranial vessels of cat and man.
In intraand extracranial arteries from cat and man (under conditions in which dilation was blocked), 5-hydroxytryptamine (5-HT) and D-lysergic acid diethylamide (LSD) produced a contraction at lower doses than that produced by tryptamine. Methysergide inhibited the S-HT-induced contraction of the extracranial arteries in a competitive manner. In intracranial arteries the inhibition comprised a ...
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Pretreatment of pancreatic acini with 5-hydroxytryptamine (5-HT) reduced the binding of the labeled somatostatin (SS) analogue 125I-Tyr3-SMS to pancreatic acinar membranes. This effect was dependent of the dose of 5-HT used and length of pretreatment. This inhibitory effect of 5-HT was abolished when pancreatic acini were pretreated with 5-HT in the presence of the 5-HT1p receptor-antagonist 5-...
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Serotonin (5-hydroxytryptamine; 5-HT) is a potent stimulator of aldosterone secretion in the rat adrenal gland but the type of receptor involved in the mechanism of action of 5-HT remains unknown. The aim of the present study was to determine the pharmacological profile and to clone the receptor responsible for the corticotropic effect of 5-HT in rat glomerulosa cells. A series of 10 serotonerg...
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Because few previous studies have investigated the mechanisms of endotoxin translocation induced by intestinal obstruction, we aimed to clarify whether or not serotonin [5-hydroxytryptamine (5-HT)], which is released from enterochromaffin (EC) cells, is responsible for alterations of the mucosal permeability to endotoxin and to identify the 5-HT receptor subtypes that mediate this action. FITC-...
متن کامل5-hydroxytryptamine and its receptors in systemic vascular walls.
5-hydroxytryptamine (5-HT) in the bloodstream is largely contained in platelets and circulates throughout the entire vascular system. 5-HT released from activated platelets dramatically changes the function of vascular smooth muscle cells (VSMCs) and endothelial cells (ECs). In VSMCs, 5-HT induces proliferation and migration via 5-HT2A receptors. These effects are further enhanced by vasoactive...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1974
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)32284-x